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In a fixed-dose study comparing placebo and 10, 20, and 40 mg of paroxetine tablets in the treatment of panic disorder, there was no clear relationship between adverse events and the dose of paroxetine tablets to which patients were assigned, except for asthenia, dry mouth, anxiety, libido decreased, tremor, and abnormal ejaculation.
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this table also shows those events that were dose dependent indicated with an asterisk as defined as events having an incidence rate with 25 mg of paroxetine hydrochloride controlled-release tablets that was at least twice that with 12.
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at steady state, when the cyp2d6 pathway is essentially saturated, paroxetine clearance is governed by alternative p 450 isozymes that, unlike cyp2d6, show no evidence of saturation see precautions tricyclic antidepressants tcas .
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